Formoterol dry powder in asthma.
نویسنده
چکیده
We read with interest the paper by Douglas and coworkers (July 1993;48,719-21) on the possible inheritance of sleep disturbed breathing. Investigating 40 first degree relatives of patients with sleep apnoeas, they found a high prevalence of sleep apnoeas/ hypopnoeas (25%), several times higher than the prevalence in a random sample of the British population (5%).' The authors concluded that a familial predisposition to sleep apnoeas/hypopnoeas is probable. If such a predisposition is inheritable, so must be the first stage of the syndrome that is, habitual snoring.2 To test this hypothesis we analysed the results of a questionnaire
منابع مشابه
Health outcomes, education, healthcare delivery and quality – 3057. Randomized, double blind comparative study to assess safety, efficacy with mometasone & formoterol versus fluticasone & formoterol dry powder inhaler (DPI) in the treatment of mild to moderate persistent asthma
Background Asthma is a problem worldwide, with an estimated 300 million affected individuals. Mometasone being newer drug has low systemic bioavailability, high glucocorticoid receptor affinity and modifies inflammatory mediators involved in the pathogenesis of asthma. Mometasone significantly improves PFT and symptom control in patients with asthma when used in combination with Formoterol. The...
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BACKGROUND Formoterol, a new beta 2 agonist, is long and fast acting when given as an aerosol. The aim was to determine the onset and duration of bronchodilatation with formoterol as a dry powder compared with salbutamol dry powder and with placebo. METHODS Fifteen patients with stable asthma with a reversibility of 15% or more participated in a double blind, within patient study. On five dif...
متن کاملFlow-dependent effect of formoterol dry-powder inhaled from the Aerolizer.
The output and size distribution of aerosols from dry powder inhalers are dependent on the flow rate through the device. Therefore, in an in vivo study, we examined the flow-dependency of the effect of formoterol when delivered from a dry powder inhaler, the Aerolizer, in a flow range relevant to schoolchildren. In a preliminary study comprising 126 asthmatic children aged 3-10 yrs, the relatio...
متن کاملAsthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation
BACKGROUND Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers. Using real-life situations this study was designed to evaluate asthma control in outpatients with moderate to severe persistent asthma and to compare efficacy of fixed combinations of inhaled corticosteroids (ICS) and long acting beta-ago...
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• Asthma and chronic obstructive pulmonary disease (COPD) are common respiratory conditions that represent a considerable cost burden to the Spanish healthcare system1. • Symbicort® Turbuhaler® (budesonide + formoterol fumarate dihydrate) and Seretide® Accuhaler® (fluticasone propionate + salmeterol) are commonly used dry powder inhalers (DPIs) in Spain, and can be difficult for patients to tra...
متن کاملFluticasone/formoterol dry powder versus budesonide/formoterol in adults and adolescents with uncontrolled or partly controlled asthma.
UNLABELLED This 12-week study compared the efficacy and safety of a fixed combination of fluticasone propionate plus formoterol (FL/F) 250/12 μg b.i.d. administered via a dry powder inhaler (DPI) (Libbs Farmacêutica, Brazil) to a combination of budesonide plus formoterol (BD/F) 400/12 μg b.i.d. After a 2-week run-in period (in which all patients were treated exclusively with budesonide plus for...
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عنوان ژورنال:
- Thorax
دوره 49 1 شماره
صفحات -
تاریخ انتشار 1994